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MD/PhD student
B.S. in Chemistry, Pacific Lutheran University, Tacoma, WA 2018
Research Keywords: Cereblon, molecular glues, NUT carcinoma, PrOF NMR
Biography
Biography
Elliott was raised in Washington State and earned his B.S. in Chemistry from Pacific Lutheran
University. As an undergraduate, Elliott worked with Prof. Jon Freeman and Prof. Neal Yakelis
on the synthesis of ethylene-linked calixarene dicavitand scaffolds for developing de novo four-
helix bundle metalloenzymes. He also spent a summer at the University of Minnesota working in
the lab of Dr. Douglas Yee, MD, investigating how small protein scaffolds could inhibit insulin
receptor-mediated signaling in triple-negative breast cancer cell models. Upon graduation from
PLU, Elliott moved to the University of California, San Francisco, to join the lab of Dr. Mark
Moasser. Here, Elliott’s work focused on the molecular biology of tumorigenic kinase signaling,
specifically the signaling and structure-function biology of the HER2, HER3, and Src kinases.
This work was published in Cell Reports and Molecular Cancer Research.
In 2022, Elliott joined the Medical Scientist Training Program (MSTP) at the University of
Minnesota, and rotated in the labs of Profs. Pomerantz, Levinson, and Harki, before ultimately
joining the Pomerantz lab in the summer of 2024. Elliott is interested in synthetic medicinal
chemistry, biophysics, and structural dynamics, and is incorporating these scientific techniques
in his work on the E3 ubiquitin ligase receptor Cereblon and his work on the epigenetic
regulation and signaling mechanisms of the BRD4-NUT fusion protein in NUT carcinomas.
Publications
Publications
Extensive Conformational and Physical Plasticity Protects HER2-Her3 Tumorigenic Signaling
Campbell, M. R.; Ruiz-Saenz, A.; Zhang, Y.; Peterson, E.; Steri, V.; Oeffinger, J.; Sampang, M.; Jura, N.; Moasser, M. M. Extensive Conformational and Physical Plasticity Protects HER2-Her3 Tumorigenic Signaling. Cell Reports 2022, 38 (5), 110285. DOI:10.1016/j.celrep.2021.110285. PMCID: PMC8865943
Targetable HER3 Functions Driving Tumorigenic Signaling in HER2-Amplified Cancers
Campbell, M. R.; Ruiz-Saenz, A.; Peterson, E.; Agnew, C. R.; Ayaz, P.; Garfinkle, S.; Littlefield, P.; Steri, V.; Oeffinger, J.; Sampang, M.; Shan, Y.; Shaw, D. E.; Jura, N.; Moasser, M. M. Targetable HER3 Functions Driving Tumorigenic Signaling in HER2-Amplified Cancers. Cell Reports 2022, 38 (5), 110291–110291. DOI:10.1016/j.celrep.2021.110291. PMCID: PMC8889928
Proteomic Analysis of Src Family Kinase Phosphorylation States in Cancer Cells Suggests Deregulation of the Unique Domain
Ruiz-Saenz, A.; Zahedi, F.; Peterson, E.; Yoo, A.; Dreyer, C. A.; Spassov, D. S.; Oses-Prieto, J.; Burlingame, A.; Moasser, M. M. Proteomic Analysis of Src Family Kinase Phosphorylation States in Cancer Cells Suggests Deregulation of the Unique Domain. Molecular Cancer Research 2021. DOI: 10.1158/1541-7786.mcr-20-0825. PMCID: PMC8178206
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