Cole Scholtz
graduate student
Biography
Cole was raised on the outskirts of Kansas City, MO and earned his B.S. in Chemistry from the University of Central Missouri in 2020. While there, he worked with Prof. Jay Steinkruger and Prof. Chen Zhou in developing thiolated-dipeptide ligands to investigate the fluorescent and physical properties of luminescent gold nanoparticles for biomedical imaging. Additionally, he spent a summer at the University of Utah under Prof. Scott Anderson investigating electrocatalysis of glycerol using Pt-nanocluster model systems. As a part of the LANDO program at the University of Minnesota in 2019, Cole worked to synthesize chemical probes to inhibit the bromodomain-containing protein BPTF under Prof. William Pomerantz. Cole then transitioned to Prof. Pomerantz’s lab in the fall of 2020, where he develops selective degraders for the epigenetic protein BRD4 for the treatment of multiple myeloma. In his free time, Cole prioritizes being outdoors and in nature to fish and hike, and also enjoys board games.
B.S. in Chemistry
University of Central Missouri, 2020
M.S. in Chemistry
University of Minnesota-Twin Cities, 2022
Research Keywords: Bromodomain inhibitors, PROTACs
Publications
Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader
Divakaran, A.; Scholtz, C.R.; Zahid, H.; Lin, W.; Griffith, E.C.; Lee, R.E.; Chen, T.; Harki, D.A.; Pomerantz, W.C.K. ACS Med. Chem. Lett. 2022, TBA.
A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes
Cui, H.; Divakaran, A.; Hoell, Z.J.; Ellingson, M.O.; Scholtz, C.R.; Zahid, H.; Johnson, J.A.; Griffith, E.C.; Gee, C.T.; Lee, A.L.; Khanal, S.; Shi, K.; Aihara, H.; Shah, V.H.; Lee. R.E.; Harki, D.A.; Pomerantz, W.C.K. J. Med. Chem. 2022, 65, 3, 2342–2360.
Exploration of Surface Chemistry Effects on the Biodistribution and Pharmacokinetics of Dual-Ligand Luminescent Gold Nanoparticles
Lin, Y.; Yong, S.; Scholtz, C.R.; Du, C.; Sun, S.; Steinkruger, J.D.; Zhou, X.; Zhou, C.; Yang, S. Exploration of Surface Chemistry Effects on the Biodistribution and Pharmacokinetics of Dual-Ligand Luminescent Gold Nanoparticles. Colloids Surf. A: Physiochem. Eng. 666 (2023), 131316.
