Caroline Buchholz
graduate student
Biography
Caroline grew up in Bloomington, Minnesota before earning her B.S. in Chemistry at Iowa State University in 2018. While at Iowa State she worked in a nanomaterials and catalysis lab with Dr. Huang before switching to organic synthesis of photocages in the lab of Dr. Winter. Additionally, she spent at summer at the University of Minnesota doing research in the pharmacology department on kinase allosteric mechanisms with Dr. Levinson. After coming back to the University of Minnesota for graduate school she joined the Pomerantz lab. Caroline studies the epigenetic protein BPTF, working on bromodomain probe development and PHD finger fragment screening. For fun, she likes to read and spend time at the lake.
B.S. Chemistry, Iowa State University, 2018
Research Keywords: Bromodomains, Inhibitors of methyl lysine binding proteins, FBDD
Publications
pH Effects Can Dominate Chemical Shift Perturbations in 1H, 15N-HSQC NMR Spectroscopy for Studies of Small Molecule/α-Synuclein Interactions
Pandey, A.K.; Buchholz, C.R.; Kochen, N.N.; Pomerantz, W.C.K.; Braun, A.R.; Sachs, J.N. ACS Chem. Neurosci. 2023, 14, 4, 800-808.
New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition
Zahid, H.; Buchholz, C.R.; Singh, M.; Ciccone, M.F.; Chan, A.; Nithianantham, S.; Shi, K.; Aihara, H.; Fischer, M.; Schönbrunn, E.; dos Santos, C.O.; Landry, J.W.; Pomerantz, W.C.K. J. Med. Chem. 2021, 64, 18, 13902–13917.
19F NMR viewed through two different lenses: ligand-observed and protein-observed 19F NMR applications for fragment-based drug discovery
Buchholz, C.R. and Pomerantz, W.C.K. RSC Chem. Biol., 2021, 2, 1312-1330
4-Methyl-1,2,3-Triazoles as N-Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity
Cui, H.; Carlson, A.C.; Schleiff, M.A.; Divakaran, A.; Johnson, J.A.; Buchholz, C.R.; Zahid, H.; Vail, N.R.; Shi, K.; Aihara, H.; Harki, D.A.; Miller, G.P.; Topczewski, J.J.; Pomerantz, W.C.K. J. Med. Chem., 2021, 64, 14, 10497–10511.
