Not pictured: Jeff
Our Research: Our overarching goal is to discover new ways to inhibit protein-protein interactions (PPIs) involved in transcription. Our research seeks to understand the molecular level details of transcription factor-protein interactions and epigenetic complexes which control how our genetic information is expressed. At the same time, we use chemistry to design synthetic molecules that disrupt the dysregulated forms of PPI communication to further understand the underlying biology and treat disease. We apply NMR and MRI, to visualize biomolecular interactions, and use small molecules that we synthesize in the laboratory to perturb the protein function. Students and postdocs working in this area are exposed to broad training in organic synthesis, protein biochemistry, fragment-based drug design and additional applied biophysics techniques to validate our 19F NMR approach.
Given that transcription factors represent a major class of potential drug targets and the demand for structural methods to characterize them, our biomolecular 19F NMR approach for transcription factor-PPIs could significantly increase the repertoire of new targets and open up new paths forward for small molecule discovery.