Nora Vail
graduate student
Biography
Nora is a New Jersey native who studied chemistry at Ithaca College, where she dipped her toe in several different fields of chemistry on her path to earning her BS. After joining the lab in 2020, Nora began working on the design and synthesis of triazole-based BET inhibitors for the treatment of inflammatory diseases such as alcoholic hepatitis. Outside of the lab, Nora serves as the outreach officer for the Chemistry Department chapter for Women in Science and Engineering. In her free time, Nora is an obsessive baseball fan (let’s go Mets!), an avid horror and thriller reader, and a beach bum.
Email: vail0049@umn.edu
Twitter: @norvailine
B.S. in Chemistry
Ithaca College, 2020
Research Keywords: Selective BET bromodomain Inhibitors
Publications
4-Methyl-1,2,3-Triazoles as N-Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity
Cui, H.; Carlson, A.C.; Schleiff, M.A.; Divakaran, A.; Johnson, J.A.; Buchholz, C.R.; Zahid, H.; Vail, N.R.; Shi, K.; Aihara, H.; Harki, D.A.; Miller, G.P.; Topczewski, J.J.; Pomerantz, W.C.K. J. Med. Chem., 2021, 64, 14, 10497–10511.
Design, synthesis, and evaluation of transition-state analogs as inhibitors of the bacterial quorum sensing autoinducer synthase CepI
Higgins, E. L.; Kellner-Rogers, J. S.; Estanislau, A. M.; Esposito, A. C.; Vail, N. R.; Payne, S. R.; Stockwell, J. G.; Ulrich, S. M. Design, Synthesis, and Evaluation of Transition-State Analogs as Inhibitors of the Bacterial Quorum Sensing Autoinducer Synthase CepI. Bioorganic & Medicinal Chemistry Letters 2021, 39, 127873.
Enhanced Affinity for 3-Amino-Chromane-Derived σ1 Receptor Ligands
Porter, M. R.; Xiao, H.; Maity, S.; Vail, N.; Smith, S. B.; Topczewski, J. J. Enhanced Affinity for 3-Amino-Chromane-Derived Σ1 Receptor Ligands. ACS Omega 2020, 5 (50), 32724–32737.
